RAF Typhoon FGR4s have conducted a mission with France's air force in a coordinated attack targeting an hidden munitions depot in Syria used by the IS group, according to the UK's MoD.
The site, pinpointed through reconnaissance, was thought to be housing weapons and explosive materials, the statement said, and was situated in mountainous terrain just above the historic site of Palmyra in Syria's central region.
"Our fighter planes employed Paveway IV guided bombs to strike a number of entry passages leading to the depot... early reports are that the strike was effective," the MoD said.
There was no indication of any harm to civilians in the operation conducted Saturday night and all the aircraft made a safe return, the defence officials confirmed.
The Typhoon FGR4s were backed up by a Voyager aerial refuelling aircraft.
IS - alternatively referred to as ISIS - imposed jihadist rule over large swathes of Iraq and Syria prior to its 2019 collapse.
"This operation underscores the UK's leading role, and commitment to work closely with allied nations, to eradicate any revival of Daesh and their dangerous and violent ideologies in the Middle East," the British Defence Secretary the Defence Secretary remarked.
British military aircraft have performed surveillance missions over Syria to "prevent any attempted resurgence" of IS subsequent to its routing at the climactic battle in Baghuz in 2019, the authorities noted.
"I must thank the personnel of the UK armed forces involved in this strike for their professionalism and their bravery," he added. "Including them were thousands of British troops deployed over the holidays. This mission, to take out militants who endanger our way of life, shows how our armed forces are ready to step up, throughout the year, protecting the UK within its borders and powerful internationally."
In December, the United States armed forces conducted what it described as a "massive strike" on Islamic State objectives in the country, subsequent to an assault killed two US servicemembers and a civilian linguist in Palmyra.
The UN says Islamic State still boasts roughly 5-7 thousand fighters in Iraq and Syria.
